Dexamethasone, a glucocorticoid with anti-inflammatory and immunosuppressive effects, can transiently increase the expression of therapeutic genes delivered using adeno-associated virus (AAV) vectors. CU Boulder News & Events: RNA binding by the glucocorticoid receptor attenuates dexamethasone-induced gene activation (Scientific Reports 2023) RNA binding by the glucocorticoid receptor attenuates dexamethasone-induced gene activation (Scientific Reports 2023) News Medical: Dexamethasone administration at a late time point could enhance transgene expression The glucocorticoid receptor (GR) is a ligand-activated transcription factor that regulates a suite of genes through direct binding of GR to specific DNA promoter elements. GR also interacts with RNA, ...
Dexamethasone has been highlighted as an effective medicine against severe coronavirus disease 2019 (COVID-19) since the early stages of the pandemic, being more potent with a longer plasma half-life ... The New England Journal of Medicine: Effect of Glucocorticoids on Plasma Insulin ALTHOUGH the diabetogenic activity of adrenoglucocorticoids has been studied extensively in terms of increased gluconeogenesis and impaired peripheral glucose utilization 1–4 the effects of these ...
